My site now has smart quotes thanks to SmartyPants.
It’s a plugin for Moveable Type, that takes the standard straight quotes and apostrophes and makes them the curly type.
I think this not only looks really nice, but helps readers more easily (read subconciously) move into and out of quotes.
Reader’s eyes have been trained by print to expect the shape of the quote mark to indicate whether they’re beginning or ending a quote.